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Common low-penetrance risk variants associated with breast cancer in Persian women

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Year: 2016
COI code: IPMCMED01_087
Paper Language: English

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Authors Common low-penetrance risk variants associated with breast cancer in Persian women

  Hamidreza Agha Heydarali Naghash - Karaj Branch, Islamic Azad University,Karaj,Iran
  Ali Salehzadeh - Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran
  Ashkan Alborzi - Islamshahr Branch, Islamic Azad University, Islamshahr, Iran
  Shima Forouzan - Islamshahr Branch, Islamic Azad University, Islamshahr, Iran

Abstract:

Breast cancer is a disease caused by a complex combination of genetic and environmental factors. Several genes are known to be associated with increased susceptibility to breast cancer , including BRCA1 (Breast cancer 1 gene), BRCA2 (Breast cancer 2 gene), ATM (ataxia-telangiectasia mutated gene) etc., but only about 5% of breast cancer incidence can be explained by these high-penetrance mutations.Therefore, the identification of low-penetrance genes/loci may have a significant impact on breast cancer risk estimation.Single nucleotide polymorphisms (SNPs) lead to genetic differences in breast cancer susceptibility among women from different ethnicities. In unselected breast cancer patients, genome-wide association studies have identified low penetrance, high frequency SNPs that are associated with breast cancer risk.A recent multi-stage genome-wide scan for associations has identified five low-penetrance loci that are strongly associated with breast cancer in populations of diverse ethnicity. Four of them contain plausible causative genes FGFR2 (fibroblast growth receptor 2), TNRC9 (Trinucleotide repeat-containing 9), MAP3K1 (mitogen-activated protein kinase 3 K1), and LSP1 (lymphocyte-specific protein 1).In this study, the associations between FGFR2 (rs2981582, rs1219648),MAP3K1(rs889312 ),TOX3 (rs3803662, rs8051542,rs12443621,rs3104746,rs4784227) and LSP1 (rs3817198 ) polymorphisms and breast cancer risk will validate in our Persian population.

Keywords:

Breast cancer , SNP, FGFR2 ,MAP3K1 ,LSP1

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Agha Heydarali Naghash, Hamidreza; Ali Salehzadeh; Ashkan Alborzi & Shima Forouzan, 2016, Common low-penetrance risk variants associated with breast cancer in Persian women, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_087.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Agha Heydarali Naghash, Hamidreza; Ali Salehzadeh; Ashkan Alborzi & Shima Forouzan, 2016)
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Type: Azad University
Paper No.: 7228
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