The Role of Slit-Robo Signaling as a Therapeutic Target for Cancers

Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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IPMCMED01_098

تاریخ نمایه سازی: 23 آذر 1397

Abstract:

Abstract Introduction & Aim: Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo interactions are involved in many pathological cellular processes, including cell cycle, apoptosis, cell adhesion, motility, angiogenesis and invasion, which are important for tumorigenesis, cancer progression and metastasis. The current available data suggest that the Slit-Robo pathway could be a promising target for development of anticancer drugs. The aim of this report is to summarize the studies of the role of Slit-Robo signaling in cancer progression, metastasis and therapeutic potential.Method: the search was done in electronic databases using the following keywords: Slit-Robo pathway, cancers, anticancer, therapeutic, and personalized medicine. Results: The current data show that Slit-Robo pathways differentially modulate invasion and migration, which varies according to signaling and type of cancers. On the other hand, in most of the cancer types, Slit-Robo acts as a tumor suppressor, except in some gastrointestinal cancers. The activation or suppression of the Slit-Robo pathway modulates several oncogenic pathways that are associated with the development and progression of cancer. The findings demonstrate the angiogenic function of Slit-Robo signaling indicate the effectiveness of blocking this signaling pathway in treating cancers. It can be translated to the diagnosis, treatment, and prevention of malignant tumors remains to be determined.Conclusion: Data demonstrated the role of Slit-Robo signaling in tumor angiogenesis and have evaluated the significance of this signaling pathway in the pathogenesis of cancers. Results indicate therapeutic potential of understanding Slit and Robo signaling, and this is likely to remain an active area of investigation. Even though the road to Slits and Robos as potential drug targets or biomarkers of cancers is still long, but the hope is that such a personalized strategy in cancer therapy will replace the conventional one-size-fits-all cytotoxic chemotherapy approach.

Authors

Flora Forouzesh

Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

Seyed Omidreza Mousavi

Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran