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A common gene expression signature in three gastrointestinal malignancies: Gastric cancer, Colorectal cancer and Hepatocellular carcinoma

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Year: 2016
COI code: IPMCMED01_102
Paper Language: English

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Authors A common gene expression signature in three gastrointestinal malignancies: Gastric cancer, Colorectal cancer and Hepatocellular carcinoma

  Kaveh Baghaei - Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Nazanin Hosseinkhan - Research Institute for Gastroenterology and Liver Diseases
  Hamid Asadzadeh Aghdaei - Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  Mohammad reza Zali - Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract:

Recently traditional histopathologic characterizations of cancers is having been replaced by high throughput molecular based methods which study genome scale gene expressional pattern, copy number variations and epigenetic modifications. According to GLOBOCAN 2012, the incidence and the mortality rate of colorectal, gastric and liver cancers are the highest among the total gastrointestinal cancers. In this study in order to find common genes and pathways simultaneously dysregulated in the colorectal cancer, gastric cancer and hepatocellular carcinoma, we conducted differentially expression analysis between three high quality microarray gene expression datasets. The results showed 23 overlapping differentially expressed genes (DEGs) in three cancers. Inspecting the common inferred regulatory network of these genes in the understudied cancers resulted in the detection of two cases of potential feed forward loops (FFLs) indicating cross-talk between cancers associated pathways. The result of vulnerability test of the common protein protein interaction (PPI) network in the three cancers suggested three candidates which their simultaneous targeting will disintegrate the main parts of the network and consequently are potential options for efficient treatment strategies. In total the results of this study introduces new common potential biomarkers in colorectal cancer, gastric cancer and hepatocellular carcinoma that monitoring their expressional changes in suspicious patients can be helpful in prognosis of these gastrointestinal cancers at early stages.

Keywords:

common expressional pattern, gastrointestinal cancers, regulatory network, PPI network

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COI code: IPMCMED01_102

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Baghaei, Kaveh; Nazanin Hosseinkhan; Hamid Asadzadeh Aghdaei & Mohammad reza Zali, 2016, A common gene expression signature in three gastrointestinal malignancies: Gastric cancer, Colorectal cancer and Hepatocellular carcinoma, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_102.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Baghaei, Kaveh; Nazanin Hosseinkhan; Hamid Asadzadeh Aghdaei & Mohammad reza Zali, 2016)
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