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Cyp2c8 GENE POLYMORPHISM AT POSITION cyp2c8 2 805 (A → T) IN HEALTHY POPULATION OF WEST MAZANDARAN PROVINCE

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Year: 2016
COI code: IPMCMED01_108
Paper Language: English

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Authors Cyp2c8 GENE POLYMORPHISM AT POSITION cyp2c8 2 805 (A → T) IN HEALTHY POPULATION OF WEST MAZANDARAN PROVINCE

  Sarvenaz Sadeghi - Department of Biology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
  Somayeh Assadian Narenji - Department of Biology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran

Abstract:

Personalized medicine is a form of medicine that uses information about a persons genes, proteins, and environment to prevent, diagnose and treatment of disease. The exact purpose of showing certain elements in personalized medicine is based on an individual analysis of genomic and biological factors and lifestyle person When you choose the right medication at the right time with the disease s treatment However, such tests can test applications in personalized medicine point out that CYP2C8 genotype of cytochrome P450 enzymes of the cytochrome P450 family plays an important role in the metabolism of a variety of exogenous and endogenous compounds and drugs .this study aimed to investigate common polymorphisms in gene cyp2c8a in healthy population of west Mazandaran province to determine the polymorphism of this gene in the population studied. A total of 200 unrelated healthy volunteers living in Tonekabon, Ramsar during the period January to March 94 were referred to the laboratory. 5 mL of peripheral blood was taken from each subject and DNA was extracted using phenol-chloroform method and the PCR-RPLP method for determining the genotype of the polymorphism CYP2C8 2 805 (A → T) was used. The frequencies of genotypes AA, AT, TT, respectively, 85%, 7.5%, 7.5%, respectively P≤0.05)) based on the results obtained in this study, among the 200 samples analyzed, the highest genotype is homozygous AA. The results of this study to understand the distribution polymorphism 805 (A → T) of the genes CYP2C8 2. Results also can help predict the risk of diseases such as cancer, cardiovascular disease, hypertension and parasites, and Falciparum drug metabolism and drug benefit in this population.

Keywords:

personalized medicine, cytochrome P450, CYP2C8 2, polymorphism, cancer

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COI code: IPMCMED01_108

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Sadeghi, Sarvenaz & Somayeh Assadian Narenji, 2016, Cyp2c8 GENE POLYMORPHISM AT POSITION cyp2c8 2 805 (A → T) IN HEALTHY POPULATION OF WEST MAZANDARAN PROVINCE, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_108.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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Type: Azad University
Paper No.: 1867
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