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Genetic variants at the TERT- CLPTM1L locus associate with many cancer types

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Year: 2016
COI code: IPMCMED01_119
Paper Language: English

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Authors Genetic variants at the TERT- CLPTM1L locus associate with many cancer types

Hamed Nikjou - Islamic Azad University,Gorgan
  Hamidreza Agha Keydarali Naghash - Karaj Branch, Islamic Azad University,Karaj,Iran
  Massoud Houshmand - National Institute of Genetic Engineering and Biotechnology (NIGEB),Tehran,Iran

Abstract:

Cancer is caused by a complex interplay between genetic and environmental factors. Highly penetrant mutations explain only a small fraction of cancer cases and the majority of genetic cancer risk is thought to be due to the contribution of many common sequence variants of low penetrance. In the past few years (GWA) studies have identified multiple single-nucleotide polymorphisms (SNPs) on chromosome 5, to breast, prostate, colorectal, and bladder cancer susceptibility.Rafnar et al. have discovered sequence variants in the region of the TERT and CLPTM1L genes that associate with risk of many types of cancer, and assessed the association of rs401681(C)) and rs2736098(A) with the major histological types of cancers.Rs401681 resides in an LD block that contains the CLPTM1L (cisplatin resistance related protein CRR9p) gene and the 5′ end of the TERT (human telomerase reverse transcriptase) gene. CLPTM1L is a predicted transmembrane protein that is expressed in a range of normal and malignant tissues including skin, lung, breast, ovary and cervix.Rs2736098 corresponds to A305A in the second exon of the TERT gene while rs401681 is in an intron of the CLPTM1L gene.In this study, We will test the joint effect of rs401681(C) and rs2736098(A) to find association with 5 cancer types in cancer cases ( lung, breast , prostate, colorectal and bladder ) and controls in Iranian population.

Keywords:

Cancer, SNP, CLPTM1L ,TERT

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COI code: IPMCMED01_119

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Nikjou, Hamed; Hamidreza Agha Keydarali Naghash & Massoud Houshmand, 2016, Genetic variants at the TERT- CLPTM1L locus associate with many cancer types, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_119.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Nikjou, Hamed; Hamidreza Agha Keydarali Naghash & Massoud Houshmand, 2016)
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