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Evaluation of Aflibercept effect on VEGF gene expression in CAFs and CAFs/epithelial cells of Oral Squamous Cell Carcinoma

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Year: 2016
COI code: IPMCMED01_127
Paper Language: English

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Authors Evaluation of Aflibercept effect on VEGF gene expression in CAFs and CAFs/epithelial cells of Oral Squamous Cell Carcinoma

  Masoumeh Mirkeshavarz - Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences
  Ahmad Nasimian - Human and Animal cell Bank, Iranian Biological Resource Center (IBRC), ACECR
  Pouyan Aminishakib - Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences
  Meysam Ganjibakhsh - Human and Animal cell Bank, Iranian Biological Resource Center (IBRC), ACECR

Abstract:

Introduction: Oral cancer is the tenth most common cancer in Iran. The main reason of poor prognosis is early, distant metastasis. Recent investigations show tumor stroma and especially Cancer-Associated Fibroblasts (CAFs) have a considerable role in angiogenesis and consequently tumor progression. In the present study we investigated and compared the anti-angiogenic impact of Aflibercept (Anti-cancer drug) in both CAFs and CAFs/epithelial cells co-culture.Materials and Methods: After obtaining tissue samples from an oral cancer patient, CAFs and CAFs/epithelial cells were isolated using enzymatic digestion and explant culture. VEGF gene expression were investigated using Real-Time PCR before and after treatment by Aflibercept.Results: VEGF gene expression was significantly increased in CAFs/epithelial cells co-culture comparing with CAFs. After treatment by Aflibercept, although VEGF gene expression was decreased, it was not significant.Conclusion: Although Aflibercept may confine oral squamous cell carcinoma progression through decreasing VEGF gene expression, it seems other molecular factors interfere this process.

Keywords:

Oral Squamous Cell Carcinoma; Aflibercept; Carcinoma Associated Fibroblast

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COI code: IPMCMED01_127

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Mirkeshavarz, Masoumeh; Ahmad Nasimian; Pouyan Aminishakib & Meysam Ganjibakhsh, 2016, Evaluation of Aflibercept effect on VEGF gene expression in CAFs and CAFs/epithelial cells of Oral Squamous Cell Carcinoma, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_127.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Mirkeshavarz, Masoumeh; Ahmad Nasimian; Pouyan Aminishakib & Meysam Ganjibakhsh, 2016)
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Type: Medical University
Paper No.: 6375
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