CIVILICA We Respect the Science
Publisher of Iranian Journals and Conference Proceedings

Functional application of Personalized Medicine in Cardiovascular Disease

Credit to Download: 0 | Page Numbers 1 | Abstract Views: 127
Year: 2016
COI code: IPMCMED01_129
Paper Language: English

How to Download This Paper

For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.

Authors Functional application of Personalized Medicine in Cardiovascular Disease

  Mahsa A le-ebrahim - Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran


Cardiovascular diseases (CVDs) accounts for 30% of deaths worldwide, including nearly 40% in high-income countries and about 28% in low- and middle-income countries. There was a remarkable growth in scientific publication on personalized medicine within the past few years in the cardiovascular field. We can classify personalized medicine into comprehensive, genomics, structural and functional fields. Examples of functional factors include endothelial function, exercise testing, and heart rate variability. Endothelial dysfunction is a novel target for CVDs risk reduction and therefore is of great interest to interventionists. The endothelium regulates vascular tone through releasing several vasoactive substances, like nitric oxide. The nitric oxide mediates the protection of the endothelium by limiting the vascular inflammation, vascular smooth muscle proliferation, platelet aggregation, and tissue factor production. Endothelial function can be tested by flow-mediated dilation (FMD) in the brachial artery. The treatment of coronary heart disease reverses endothelial dysfunction, including drugs that modify lipids and reduce blood pressure, along with smoking cessation, physical exercise, and dietary intervention. One of the alternative methods for measuring endothelial function is the noninvasive peripheral arterial tonometry that examines the endothelial dysfunction and can predict late cardiovascular events. The Reactive hyperaemia (RH) response with peripheral arterial tonometry as detected by the RH index is another useful technique for detecting the CVDs and it has been shown to be related to multiple traditional and metabolic risk factors. Also, pulse amplitude tonometry (PAT)-derived measures of arterial stiffness (augmentation index, AI) had strong repeatability. These functional fields of personalized medicine can help cardiologists to diagnosis the endothelial dysfunction and prevention of causing CVDs.


Cardiovascular diseases, personalized medicine, Endothelial function, peripheral arterial tonometry

Perma Link
COI code: IPMCMED01_129

how to cite to this paper:

If you want to refer to this article in your research, you can easily use the following in the resources and references section:
A le-ebrahim, Mahsa, 2016, Functional application of Personalized Medicine in Cardiovascular Disease, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (A le-ebrahim, Mahsa, 2016)
Second and more: (A le-ebrahim, 2016)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)


The University/Research Center Information:
Type: Azad University
Paper No.: 445
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.

Research Info Management

Export Citation info of this paper to research management softwares

New Related Papers

Iran Scientific Advertisment Netword

Share this paper


COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.