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Check increasing the expression of Ki67 cell proliferation in the hippocampus gene brain ischemia reperfusion model rats brain after pretreatment with iron oxide nanoparticles

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Year: 2016
COI code: IPMCMED01_153
Paper Language: English

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Authors Check increasing the expression of Ki67 cell proliferation in the hippocampus gene brain ischemia reperfusion model rats brain after pretreatment with iron oxide nanoparticles

Niloofar Sadeghi Mazdeh - Department of Biology,IslamshahrBranch,Islamic Azad University,Islamshahr,I ran
Leila Pishkar - Department of Biology,IslamshahrBranch,Islamic Azad University,Islamshahr,Iran
Mojtaba Falahati - Department of Nanotechnology,Faculty of Advance Sience and Technology,Islamic Azad University of Pharmaceutical Sciences(IAUPS),Tehran,Iran

Abstract:

Ischemia-reperfusion brain increasing in the developing world need access to efficient treatment procedures based on the waste Baztrmymy shows. Increased rate of proliferation and migration of endogenous neural stem cells after injury neurological damage to the central nervous system is the most important goal of regenerative medicine. It was found that neural stem cells in certain brain regions such as the hippocampus brain actively and Zyrbtny zone (SVZ) in the end there are mammals. Evidence show that iron oxide nanoparticles can induce cell cycle, cell proliferation induced by increasing the routes in some cells have shown. The purpose expansion of the study of gene expression Ki67 cell proliferation in the hippocampal brain ischemia reperfusion model rats brain after pretreatment with iron oxide nanoparticles. In this study, after induction of ischemia / reperfusion in rats and the treatment of brain 5 mg / kg and 10 mg / kg Ki67 expression levels of genes involved in cell proliferation in the hippocampus area of the brain in real time-PCR using animals Was investigated. Analysis of gene expression in the SVZ brain Ki67 animals in different groups represent appropriate and can be pre-treated with iron oxide nanoparticles dose-dependent increase in the expression of Ki67 was SVZ Accordingly, it was found that pretreatment of animals with a dose groups 10 mg / kg of iron oxide nanoparticles significantly (P-value<0.05) leads to increased expression of Ki67 antigen in cells in rats under ischemia reperfusion brain SGZ area in throughput. The results of this study seem to be pre-treated with iron oxide nanoparticles in cells by increasing the expression of Ki67 be appropriate SVZ area Enhance the proliferation of stem cells / progenitor neural ischemia reperfusion model in rats having brain.

Keywords:

key words gene expression of cell proliferation Ki67, area SVZ, ischemia reperfusion model rats brain, pretreatment, iron oxide nanoparticles

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COI code: IPMCMED01_153

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Sadeghi Mazdeh, Niloofar; Leila Pishkar & Mojtaba Falahati, 2016, Check increasing the expression of Ki67 cell proliferation in the hippocampus gene brain ischemia reperfusion model rats brain after pretreatment with iron oxide nanoparticles, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_153.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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