The study of the expression of apoptotic Bax, Bcl2 cells in the hippocampus following ischemia reperfusion model, pretreatment with nanoparticles of iron oxide in rat brain

Progressive cell death of nerve cells after injury to the central nervoussystem is known as one of the most destructive factors in nervous systemdiseases. Ischemia / reperfusion cerebral blood supply to the brain processthe sudden loss of blood supply to the brain and then return stroke duringdifferent parts of the brain under stress. Return observations have shownthat reperfusion or re-perfusion to the brain by increasing the oxygen freeradicals, mitochondrial dysfunction of neurons and activation of manysignaling pathways involved in cell death key role in the development ofneurological complications resulting from ischemia / reperfusion brainhasNanoparticles of iron oxide nanoparticles safely and with minimalcellular toxicity, which is now widely used in MRI-based brain imaging andtreatment of diseases have been Bzkhy.Studies show that the use of appropriate doses of the nanoparticles canrestrict the right of free radicals within the cell That seems to have theappropriate power to protect neurons against cell death from ischemia /reperfusion have a brain In this study, the neuroprotective effects ofischemia reperfusion model in rats brain Fe2O3 nanoparticles were studiedIn this study Alfa’ after ischemia / reperfusion brain injury in rats and treatedwith 5 mg / kg and 10 mg / kg apoptotic Bax and Bcl-2 gene expressionusing real time-PCR in the hippocampus region of the animals wasinvestigated The results of the study showed that the expression of Baxand Bcl-2 ratio and pre-boarding after ischemia / reperfusion brain usingiron oxide nanoparticles resulted in the induction of apoptosis Bax geneexpression significantly (P -Value <0.01) than the control group decreasedAccording to the results of the above study seem to be pre-treated with ironoxide nanoparticles with high potential to protect nerve cells in the brainfrom stroke are entitled.

Keywords:

apoptotic genes Bax and Bcl-2 , hippocampus , ischemiareperfusion rat model of stroke , pretreatment , Nanvzra iron oxide