Human Cancer Modeling: effects of tumor heterogeneity on personalized medicine

The extensive analysis of human cancers has shown that development and progression of somatic cancers is not just a simple linear phenomenon, but due to cellular, molecular, cytological and even pathological heterogeneity of cancer tissue cells, the prognosis, diagnosis and treatment of affected patients would be complicated for clinical and laboratory specialists or even patients and their families. A wide range of studies have been done on the characteristics of the tumor, but cancerous tissues need to be removed. To be studied outside the human body. Cancer cell lines, xenographts and etc. have significant achievements in discovering the effects of drugs,causes of initial migration of cancer cells to specific tissues and the role of stroma in the development and spread of cancer. For example, one of the most recent findings from xenographts in the field of personalizing breast cancer treatment is Her2 positive with metastasis in the brain, which include a large number of patients in this category, and so far, the reasons for the highly effective scientific and medical justification have not been explained. Therefore it is possible to represent a personalized breast cancer treatment in a microcategorized form as a potential suppressive factor of metastasis. In this article, we will try to review the use of these models to find the answer to some questions.

Keywords:

Human Cancer Modeling , Cancer heterogeneity , Individualizing treatment