Personalized sequencing for Treatment of colorectal cancer, forward personalized medicine: recent advances and future challenges

Colorectal cancer or (CRC) is a major health problem worldwide and the third most common cancer associated with significant mortality. Despite Considerable progress has been made in screening test, Survival rates from colorectal cancer (CRC) are still high due to delays in diagnosis of patients with CRC. On the other hand, in spite of a plethora of effective anticancer drugs, CRC treatment outcome is still poor on the basis of CRC heterogeneous nature unique to an individual’s tumor. An important issue have to resolve is early detection and then customize treatment in order to better clinically management of CRC in view the heterogeneity of individual patient. One of the most significant current discussions in personalized medicine is personalized sequencing recently has gained increasing attention for its prospect to individually customize medical treatment based on unique information for its biological attributes. The developments of large-scale ‘omics’ technologies parallel to sophisticated computational analyses making it possible to providing integral omics platforms and new insights into the biology of CRC. These approach might allow better clinically management at the individual patient level for both early detection and development of effective cancer treatment regimens. It is possible to hypothesize that personalized sequencing are more likely to become the paradigm of future healthcare. This review has discussed the current state of knowledge on the Personalized sequencing and new technologies such Next-generation sequencing (NGS), and challenges in CRC management, customize treatment by sequence-based platform and an insight into new approaches may help in development of personalized medicine for CRC.

Keywords:

Colorectal cancer , personalized sequencing , personalized medicine , ‘omics’ technologies