Expression of micro RNAs implicated in left ventricular hypertrophy; a systematic review

Publish Year: 1396
نوع سند: مقاله کنفرانسی
زبان: English
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IPMCMED02_099

تاریخ نمایه سازی: 29 فروردین 1397

Abstract:

Cardiovascular disease is one of the leading causes of human mortality and morbidity. Left ventricular hypertrophy (LVH) is a common finding and implicated as an important risk factor for sudden cardiac death. Recent efforts have been focused in determining novel molecular targets such as miRNAs with the goal of developing diagnostic or therapeutic tools especially in preclinical stage. Here we performed a systematically review of the literature to find correlations between miRNAs and LVH.We reviewed three databases including Pubmed, Embase and Cochrane from 2012 to 2017 using left ventricular hypertrophy and micro RNA as keywords. It resulted in identification of 91 articles. Based on exclusion criteria, 13 articles were remained to study.We observed higher expression levels of (miR-1, miR-2, miR-21, miR-22, miR-23a, miR-26b, miR-27a, miR29a, miR-29b, miR-29c, miR-133a, miR-155, miR-199a-5p, miR208, miR-208b,miR-499) and decreased levels of (miR-1, miR-9, miR-98, miR-132, miR-133, miR212, miR378) is associated with higher prevalence of LVH.The finding of this systematic review shows that different types of miRNAs play significant roles in left ventricular hypertrophy and variable expression levels of them have been seen. Our data also indicates that they are dividing in two groups including stimulatory and inhibitory miRNAs. One of the most significant findings of our study is that some of the micro RNAs including miR-1 and miR-133 are in both groups. Thus, further investigation in order to determine the exact type of miRNAs is mandatory before considering them as diagnostic tools.

Authors

Aida Iranpour

Research center for prevention of cardiovascular disease, Institute of Endocrinology & Metabolism, Iran University of medical sciences, Tehran, Iran

Reza Nekouian

Pediatric growth and development research center , Institute of Endocrinology and metabolism Iran university of medical science , Tehran , Iran

Shokoufeh Hajsadeghi

Research center for prevention of cardiovascular disease, Institute of Endocrinology & Metabolism, Iran University of medical sciences, Tehran, Iran

Reza Razzaghi

Iran University of medical sciences, Tehran, Iran