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Inhalation exposure of Manganese Dioxide nanoparticle induced oxidative stress in Melanoma

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Year: 2017
Present: شفاهي
COI code: IPMCMED02_163
Paper Language: English

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Authors Inhalation exposure of Manganese Dioxide nanoparticle induced oxidative stress in Melanoma

Vahidreza Esfahani - Islamic Azad University of Medical Science Tehran,iran
  Parvane Naserzadeh - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, P.O. Box 14155-6153, Tehran, Iran
Mehrdad Hashemi - Department of medical biotechnology Tehran Medical Science brunch Islamic azad university Tehran,iran

Abstract:

1. With the ever-increasing use of manganese dioxide (Mno2) in health-related and engineering applications, the hazardous risks of this material have become a major concern. It is well known that Mno2 accumulate with cytotoxic and genotoxic levels within vital organs. It has also been shown that treating cell cultures with Mno2 resulted in cell cycle arrest and increased apoptosis/necrosis.2. In this study, we investigated chronic exposed to Mno2 at the exposure chamber in mice. The animals were divided into two groups (control and exposed group to Mno2 at the concentration of 3 µg/m3 for 5 h/day,) in a whole-body inhalation chamber.3. Our results showed that exposure to Mno2 induced the hematological and biochemical changes. The target organs for Mno2 were the melanoma in the mice, respectively. Also, NPs increased reactive oxygen species (ROS) generation, lipid peroxidation (LPO), the collapse of mitochondrial membrane potential (MMP), decreased a level of reduced glutathione (GSH) and finally increased a level of glutathione disulfide (GSSG) in melanoma tissues. Our results suggest that exposure to Mno2 can induce oxidative stress in the tissue mentioned.4. These results suggest that exposure of researchers and workers with Mno2 probably increase a risk of respiratory, cardiovascular and cerebral disorders through oxidative stress. However, good ventilation, appropriate personal protective equipment and using of anti-oxidant compounds in daily diet of worker are suggested.

Keywords:

Mno2, chronic exposure, oxidative stress, reactive oxygen spices

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COI code: IPMCMED02_163

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Esfahani, Vahidreza; Parvane Naserzadeh & Mehrdad Hashemi, 2017, Inhalation exposure of Manganese Dioxide nanoparticle induced oxidative stress in Melanoma, 2nd International Personalized Medical Congress, تهران, دانشگاه علوم پزشكي بقيه الله(عج), https://www.civilica.com/Paper-IPMCMED02-IPMCMED02_163.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Esfahani, Vahidreza; Parvane Naserzadeh & Mehrdad Hashemi, 2017)
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