Effect of Brown algae Fucoidan on Coagulation and Thrombosis

Anticoagulant and antitrombotic properties There are 150 marine species(1), most of which belong to Phaeophyceae(2)(3). Studies have shown that fucoidan, isolated sulfate polysaccharides from algae with a high biological potential and high-tolerance properties in animals and humans regulate coagulation(4)(5)(6) , Some of them were superior to heparin(6)(7)(8)(9). Unlike heparin, which produces a rapid, but temporary, antithrombotic effect, in vivo activity of this galactofucan sulfate progresses slowly and shows maximum efficacy 8 hours after injection(10)(11). The results showed that the prothrombin time (PT) and partial thromboplastin time (APTT) have been prolonged significantly with the algae extract of Undaria Pinnatifida(12) and Sargassum vulgare(13). The prolongation of the PT time represents the inhibition of the outer pathway and the APTT inhibits the inherent pathway of coagulation(12). It has also been shown that fucoidan is regulated by interaction with antithrombin 3 or heparin cofactor 2, and has been shown to improve subcutaneous low blood coagulation in hemophilia(5). Given the current anticoagulant problems, such as heparin and warfarin, clearly requires factors such as a fucoidan that can overcome one or more problems associated with conventional anticoagulants(14). As an alternative anticoagulant source, sulphate polysaccharides have attracted a lot of attention in the pharmaceutical industry in order to develop better and safer drugs with less side effects(15)(16)(17). The development of anti-thrombosis extracts of algae will be beneficial as it prevents the risks of prion contamination and viruses in commercial heparins derived from animals(12). In addition, algae extracts of sulfate polysaccharide can be programmed Supplementary Heparin(12).

Keywords:

Anticoagulation , Antithrombotic , Brown Algae , Fucoidan , Heparin