Comparative study of two regimens therapeutic effects of clomiphene citrate and letrozole in patients with ovulatory infertility

Background and Purpose:Various medications used in the treatment of infertility, ovulation induction drugs are the most common outcome of various studies had different effects on mother or baby. Used to stimulate ovulation in women using clomiphene citrate ovulation was limited to the use of drugs such as aromatase inhibitors such as letrozole as an inexpensive, effective and low risk are proposed to induce ovulation.Methods: This study was reviewed of literature from 2009 to present.A search was preformed for articles in PubMed, Embase, the Cochrane library, Proquest, science direct and Google scholar.Findings:The number and size of mature follicles were similar for both drugs. Pregnancy rate in the letrozole groups than clomiphene groups was 6%. In 86% of patients, all of which mature follicle in letrozole showed ovulation, while the mature follicle was achieved in 72% of the clomiphene groups. Based on the large number of investigations in the event of pregnancy letrozole group (3/38%) and the clomiphene group (2/21%). The incidence of multiple pregnancy letrozole groups (8/1%) and the clomiphene group (19%) and the incidence of abortion in letrozole group (73/24%) in the clomiphene group (25%).Conclusion:It seems that letrozole in patients resistant to clomiphene citrate to induce ovulation with ovulation and pregnancy was associated with a significant amount. Due to the lack of twin pregnancy and ovarian hyperstimulation, letrozole can be the first line treatment in patients resistant to clomiphene. Studies showed that letrozole for induction of ovulation in women with polycystic ovary syndrome and infertility due to anovulation suffer, can be considered a substitute for clomiphene citrate.

Keywords:

Letrozole , Clomiphene citrate , anovulation , infertility , ovulation induction