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Pt–Au Complexes Built on a Diphosphine Scaffold: Cytotoxic Properties

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Year: 2018
COI code: IRANCC20_071
Paper Language: English

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Authors Pt–Au Complexes Built on a Diphosphine Scaffold: Cytotoxic Properties

  Samira Chamyani - Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran
  Hamid R. Shahsavari - Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran
  Mehri Khatami - Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran

Abstract:

Platinum complexes are well-established drugs in modern anticancer chemotherapy.However, their effectiveness is still hindered by clinical problems, including acquiredor intrinsic resistance, a limited spectrum of activity, and high toxicity leading to side effects [1]. A recent strategy in the field of metal based anticancer drugs consists in the design of bimetallic or even multimetallic agents bearing diverse metal centers with distinct biological and pharmacological features. This strategy is aimed at exploiting the possible synergism existing among the individual metal centers, which may contribute to overcome resistance [2]. We report here on the preparation, characterization and stability of some bimetallic Pt(II)–Au(I) complexes. The new compounds are depicted in Fig 1. They contain a cycloplatinated(II) moiety and a gold(I) chloride fragment linked through a bifunctional diphosphane ligand 1,1-bis(diphenylphosphino)methane (dppm).

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Chamyani, Samira; Hamid R. Shahsavari & Mehri Khatami, 2018, Pt–Au Complexes Built on a Diphosphine Scaffold: Cytotoxic Properties, 20th Iranian Chemical Congress, مشهد, دانشگاه فردوسي مشهد, https://www.civilica.com/Paper-IRANCC20-IRANCC20_071.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Chamyani, Samira; Hamid R. Shahsavari & Mehri Khatami, 2018)
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Paper No.: 331
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