A novel magnetic nanoparticle with morpholine tags as a multi-rule catalyst for synthesis of hexahydroquinolines

Hexahydroquinoline derivatives are ubiquitous in the nature due to their wide variety of pharmaceutical and biological applications as they can be applied as Ca2+ channelblockers. Therefore, in the recent times much attention has been focused on the topic of the synthesis of these privileged structural motifs. Also, hexahydroquinolinederivatives can be used as bronchodilators, hepatoprotective, vasodilators, antiatherosclerotic, anti-diabetic, anti-tumor agents for the treatment of cardiovasculardiseases such as hypertension [1-3]. In this exploration, we investigated the design, synthesis, characterization and catalytic performance of a novel morpholine supported based magnetic nanoparticle at the synthesis of biological active hexahydroquinoline derivatives through a four components reaction between aryl aldehydes, dimedone, ethylacetoacetate and ammonium acetate as nitrogen source