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Alkylation and cyanation of thiophene as a substance with plentiful biological properties

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Year: 2019
COI code: IRCCE06_010
Paper Language: English

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Authors Alkylation and cyanation of thiophene as a substance with plentiful biological properties

  Mehran Ghasemi - Faculty of Chemistry, Kharazmi University, No. 43. Mofateh Street, Enghelab Ave., 15719-14911 Tehran, Iran
  Azizollah Habibi - Faculty of Chemistry, Kharazmi University, No. 43. Mofateh Street, Enghelab Ave., 15719-14911 Tehran, Iran

Abstract:

Thiophene is a hetrocycle with high biological and pharmaceutical activity. Double functionalization of this compounds in one pot is one of the exciting challenges. In this study, using the Catellani strategy, it has been attempted to cyanation and alkylation the positions 2 and 3 of thiophene, respectively. One of the benefits of this reaction is the C-H activation of position 3 of thiophene followed by the formation of two carbon-carbon bonds in one pot.

Keywords:

Thiophene, C-H activation, Catellani raction, Cyanation

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COI code: IRCCE06_010

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Ghasemi, Mehran & Azizollah Habibi, 2019, Alkylation and cyanation of thiophene as a substance with plentiful biological properties, 6th International Conference on Chemical and Chemical Engineering, تهران, دبيرخانه دائمي كنفرانس, https://www.civilica.com/Paper-IRCCE06-IRCCE06_010.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Ghasemi, Mehran & Azizollah Habibi, 2019)
Second and more: (Ghasemi & Habibi, 2019)
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Type: state university
Paper No.: 9225
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