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Comparison of hyaluronic acid molecular weight for recombinant C. glutamicum at different temperatures

Credit to Download: 1 | Page Numbers 5 | Abstract Views: 83
Year: 2019
COI code: IRCCE06_063
Paper Language: English

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Authors Comparison of hyaluronic acid molecular weight for recombinant C. glutamicum at different temperatures

  Pegah Mohtaj - Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965/161, Tehran, Iran
  Fatemeh Tabandeh - Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965/161, Tehran, Iran
  Mahvash Khodabandeh - Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965/161, Tehran, Iran
  Sarah Khalaj - Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965/161, Tehran, Iran

Abstract:

Hyaluronic acid (HA) is a natural polysaccharide consist of repeating units of UDP-N-acetyl-glucosamine (UDP-GlcNAc) and UDP-glucuronic acid (UDP-GluA). Although HA is commercially produced by Streptococcus zooepidemicus, its production by GRAS microorganisms is highly recommended. In this study, two recombinant strains of Corynebacterium glutamicum harboring S. zooepidemicus and Pseudomonas putida genes were employed. HA molecular weight (MW) is an important factor which determines its application at different industries. Correlation between hyaluronic acid MW and growth temperature showed that temperature had significant impact on HA MW, but it is remarkably affected by genetic construction of the strain.

Keywords:

hyaluronic acid, hasA, bacterial fermentation, GRAS, molecular weight

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COI code: IRCCE06_063

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Mohtaj, Pegah; Fatemeh Tabandeh; Mahvash Khodabandeh & Sarah Khalaj, 2019, Comparison of hyaluronic acid molecular weight for recombinant C. glutamicum at different temperatures, 6th International Conference on Chemical and Chemical Engineering, تهران, دبيرخانه دائمي كنفرانس, https://www.civilica.com/Paper-IRCCE06-IRCCE06_063.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Mohtaj, Pegah; Fatemeh Tabandeh; Mahvash Khodabandeh & Sarah Khalaj, 2019)
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