Common rue causes oxidant/antioxidant imbalance in mouse ovarian tissue

Background: Ruta graveolens L., commonly known as rue or common rue, is traditionally used for contraceptive purposes. This murine model study was designed to explore Ruta graveolens L. aqueous extract (RGE) effects on oxidant/antioxidant status in ovarian tissue.Methods: Adult female mice were assigned into two equal groups, serving as control group and RGE-exposed group. The RGE was given to the mice at a dose of 300 mg/kg per day orally for 21 days. Twenty-one days after the last treatment, ovarian tissues were quickly harvested in order to assess malondialdehyde (MDA) and total antioxidant capacity (TAC) levels.Result: The RGE administration led to considerable reduction in TAC level along with an increase in MDA production in the mice ovarian tissue. Conclusion: Our findings suggested that RGE can cause mouse ovarian failure probably through antioxidant defense mechanisms weakening in this organ

Keywords:

Mice , Ovary , Oxidant/antioxidant balance , Ruta graveolens