Nanocurcumin can hinder oxymetholone induced spematotoxicities in mice

Background: Oxymetholone (OXM), an active, edible anabolic-androgenic steroid, is widely used by athletes as performance-enhancer in high doses. Curcumin, a hydrophobic compound naturally found in the rhizome of Curcuma Longa, has confirmed antiviral, antibacterial, antifungal, anticancer, anti-inflammatory and antioxidant properties. In the present study, the effects of nanocurcumin on mouse epididymal sperm characteristics following OXM treatment were investigated.Methods: Adult male mice were randomly divided into 4 equal groups and treated orally for 35 days. Epididymal sperm parameters were analyzed following sampling.Result: Oxymetholone (5 mg/kg) administration resulted in significant epididymal sperm concentration and quality reductions. Notably, nanocurcumin (15 mg/kg) co-treatment ameliorated above-mentioned alterations.Conclusion: It seems that nanocurcumin has potential protective activities against OXM-induced spermatotoxicities in male mice.

Keywords:

Curcumin , Mouse , Sperm , Oxymetholone