Vitamin E reduces Polyvinyl Chloride spermatotoxic effects in Rats

Background: It has been reported that polyvinyl chloride (PVC) is a potential reprotoxic agent. Vitamin E as a potent antioxidant can improve fertility outcomes. The goal of current study was to examine the possible protective effects of vitamin E against PVC-induced spermatotoxicities in rats.Methods: In this experimental study, 24 male Wistar rats were randomly categorized into four groups (n=6); control, vitamin E (150 mg/kg/day), PVC (1000 mg/kg/day) and vitamin E + PVC. Epididymal sperm characteristics were evaluated after 40 days.Result: Polyvinyl chloride-exposed rats exhibited significant reductions in sperm count, motility and viability compared to controls. Vitamin E co-administration attenuated PVC-induced epididymal sperm impairment.Conclusion: This study demonstrated that PVC has a considerable spermatotoxic effects in rats. However, vitamin E could exert protective activities against PVC-induced reproductive toxicities through oxidative stress inhibition.

Keywords:

Rat , Polyvinyl Chloride , Sperm , Vitamin E