Protective effect of Vitamin E against Polyvinyl Chloride induced destruction in Rat testicular tissue

Background: It has been suggested that polyvinyl chloride (PVC) has adverse effects on male sexual performance and testicular tissue. Vitamin E, a dietary compound with antioxidant properties, scavenges free radicals. The aim of present study was to explore the possible protective effects of vitamin E against PVC related damages in rat testicular tissue.Methods: In this experimental study, 24 male Wistar rats were randomly divided into four groups (n=6) including control, vitamin E (150 mg/kg/day), PVC (1000 mg/kg/day) and vitamin E + PVC. After 40 days, the testicular tissues of all groups were removed and prepared for histological analyses.Result: Oral administration of PVC decreased body and testes weights in the male rats. Moreover, PVC treatment caused remarkable deterioration of testicular tissue. Interestingly, vitamin E co-administration improves PVC induced injurious changes in testicular tissue.Conclusion: Polyvinyl chloride exposure can lead to significant testicular damages in rats. However, vitamin E as a powerful antioxidant may have repro-protective effects in PVC-treated animals

Keywords:

Rat , Testis , Vitamin E , Polyvinyl Chloride