Effect of Camp Analog and an Inhibitor of Phosphodiestrase on Sperm Hyper – Active Motility Patterns.

Background: The role of cAMP analog and an inhibitor of phosphodiestrase on sperm hyper – active motility has been well known. cAMP analog and an inhibitor of phosphodiestrase is routinely used for increases of motility mammalians sperm. Therefore, we decided to evaluate the effect of cAMP analog and an inhibitor of phosphodiestrase on sperm hyper – active motility patterns. Methods: Fifteen semen sampes from individuals referring to andrology unit of Qom Fertility and Infertility Center were collected for this study. All the samples were processed with DGC( Density Gradient Centrifuging ). After Incubation sperm with cAMP analog and an inhibitor ofphosphodiestrase , percentage of hyper – activated sperm was assessed using CASA ( Computer – Aided sperm Analysis) system and compared before and after incubation cAMP analog and an inhibitor of phosphodiestrase. Results: The results of this study showed that percentage of hyper – activated sperm were significantly increased after incubation with cAMP analog and an inhibitor of phosphodiestrase (P