Comparing The Outcomes of in Vitro Fertilization With or Without Prescription of Buserelin

Background: Infertility,defined as lack of pregnancy despite one-year of uncontrolled coitus, is found in 10 to 15 percent of couples in fertile ages. Today assisted reproductivetechnology (ART) is accessible worldwide, and the procedure is mainly different from that used during the early days. More recent data suggest that FET, results in significantly higher ongoing pregnancy rates compared to fresh embryo transfer. Several randomized controlled trials have been published examining the effects of different methods of endometrial preparation for cryopreserved embryo transfer, but evidence of a single best endometrium priming protocol is still lacking.Methods and materials: from 2013 to 2015, A retrospective analysis was conducted of 146 consecutive patients attending infertility treatment center, who were candidates for transfer cycle of frozen-thawed embryo. They were randomly assigned to receive either the protocol with GnRH agonist or the one without it. Then the outcomes including laboratory pregnancy rate wascompared across the groups. Results: in this study,no significant difference between results of two groups was found (P > 0.05) by Chi-Square, Fisher s Exact, McNemar,Lambda, Goodman and Kruskal, Uncertainty Coefficient, Phi, Cramer s V, Mantel-Haenszel, Cochran s, and Kendall s Tau-b tests. Conclusion: Our results indicate it may be interpreted that outcomes of IVF procedures will be same regardless of GnRH-agonists prescription for endometrial preparation. Finally, it may also be concluded that  endometrial preparation by estrogen utilization without using GnRH agonist would be as effective as those with GnRH agonist with same pregnancy rate.

Keywords:

IVF procedure , GnRH-agonist , Endometrial preparation