Carbonaceous Materials Functionalization with Multicomponent Reactions: Novel Drug Delivery Platforms

Materials functionalization with multicomponent reactions (MCRs) has definitely grabbed alot of attention nowadays due to the integration of outstanding features of MCRs with materialsdomains for the construction of neoteric bio-functional materials [1]. What causes theMCRs in the spotlight as unparalleled strategies for carbonaceous materials functionalizationis their power of one-pot which is the dream of many researchers. In this regard and basedon our previous researches in this field [2, 3], the extraordinary empirical discovery of singlepotisocyanideand Meldrum’s acid-based MCR [4] for the covalent functionalization of grapheneoxide (GO) and carbon nanotubes (CNTs) has been reported. Meanwhile, the organicmotifs that prepared with this approach are pentaamide structures that fully coated the surfaceof the carbonaceous materials and make it a great candidate for medicinal applications. Thenew synthesized pseudopeptide nanohybrids were fully characterized. Importantly, the nanobiohybridsshowed unprecedented high and long-term dispersity and stability in water. Theperformance of the nanobiohybrids for the controlled release of Tenofovir, as a model drug,was investigated and the results depicted slow drug release behavior of nanobiohybrids. Inaddition, biocompatibility and cytotoxicity of nanobiohybrids were examined and no obviousadverse effects on the viability of MCF-7 breast cancer cells were observed. The results manifestedits valuable applicability for the emerging drug delivery platforms.