Green Multi-Component Reaction of α-Haloketoneswith Acetylenic Esters in the Presence of Papaverine (Poppy alkaloid)
Publish place: 26th Iranian Seminar on Organic Chemistry
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ISOC26_155
تاریخ نمایه سازی: 2 شهریور 1398
Abstract:
Multi-component reactions (MCRs) are useful organic reactions in which three or morestarting materials react to give a product [1]. A poppy plant consists a lot of alkaloids and thisplant has been used for medical purposes since ancient times.Some opium alkaloid derivativeshave been medicinal properties, including oxycodone, oxymorphon, buprenorphine, nalbuphon[2-4]. In continuation of our quest for the synthesis of heterocyclic compounds [5], herein we describe a three-component condensation of α-haloketones1react with acetylenic esters2inthe presence of papaverine 3in water at room temperature by vigorous stirring to affordproducts 4in good to high yields.
Authors
Afsaneh Zonouzi
School of Chemistry, University College of Science, University of Tehran, Tehran, Iran- Pharmaceutical and Cosmetic Research Center (PCRC), University of Tehran, Tehran, Iran
Omid Hashemi Akhourdi
School of Chemistry, University College of Science, University of Tehran, Tehran, Iran