Magnetic Nanoparticles-Supported CuI-Caffeine: ARecyclable and Ecofriendly Catalyst for Green Synthesis of 1,2,3-Triazols from Organic Halides

1,2,3-Triazoles as vital structural scaffolds are found in a large number of biologicallyactive natural compounds and have extensive applications in medicinal chemistry, pharmaceuticalindustry [1], biochemical [2] and materials science [3]. Therefore, several investigationshave focused remarkably on such well-known structure using different catalysts. In currentresearch, we proposed a green and efficient method to prepare a value-added copper(I)–caffeine complex immobilized on silica-coated magnetite catalyst and then examined the catalyticactivity in green synthesis of 1,2,3-triazoles through the three-component reaction of variousterminal alkynes with in situ generated organic azides from organic halides in an aqueousmedium in good yields (Figure 1). Moreover, final catalyst characterized well by FT-IR,XRD, SEM, ICP, TGA and VSM techniques. The immobilized catalyst with collecting abilityvia an external magnet, reused for at least five times with little loss in activity.