Preparation and Assesment of Althaea Officinalis -Loaded Electrospun Nano Fiber

The use of nanofiber scaffold has attracted a lot of attention in recent years. For example,nanofiber scaffold is considered as suitable substrates for tissue engineering, enzymes andcatalysts stabilization, wound dressing, controlled release of drugs and artificial vessels, andin cosmetic and sanitary industries. Edible and biodegradable microspheres of chitosan wereprepared using glycolic acetic acid solvent [1,2]. Three different concentrations of chitosanand extract of Althaea officinalis solution (5%, 10%, 15%) was prepared. The optimization ofelectrospinning process and solution parameters, such as distance between needle tip, collector,electrical voltage, solution flow rate and needle size, was done by using response surfacemethod to obtain uniform chitosan nanofibers(Fig.1). The electrostatic voltage at these threeconcentrations was 10 KV, the distance between the tip of the needle and the collector at threeconcentrations was fixed at 20 cm with the flow velocity constant of 0.5 ml/h. Based on theresults, the concentration changes of the Althaea officinalis extract showed a significant effect(p ≤0 / 05) on the diameter of the fiber. As the density of concentration of the extract Althaeaofficinalis was increased, the diameter of the fibers increased.