Effect of choline chloride / malonic acid deep eutectic solvent on the acetaminophen Solubility at T = (288.15 to 318.15) K

Deep eutectic solvents (DESs) as a new class of green solvents have been used to overcome the poorsolubility of drugs during the recent years. In this work, the effect of DES containing choline chloride as hydrogenbond acceptor and malonic acid as hydrogen bond donorhas been studied on acetaminophen (ACP) solubility attemperature ranges (298.15 to 313.15) K. The results indicate that the solubility of ACP increase with increasingconcentration of DES and at higher temperatures. The solubility data were correlated by the modified Apelblat, λh(Buchowski) and Yalkowsky models which Apelblat model is more consistent with experimental data.

Keywords:

Deep eutectic solvent , Solubility , Acetaminophen , Modified Apelblat