Aqueous Solubility of Poorly Water-Soluble Drug Ibuprofen in Micellar Media: Effect of Head Groups Charge

In this study, equilibrium solubility of ibuprofen (IBP) as a poorly water-soluble drug was determined inpure water and in aqueous micellar solutions consisting of anionic SDS, cationic CTAB and non-ionic Brij-35surfactants with different concentrations and charged head groups. The solubility data show that, irrespective of thesurfactant type, the solubility of IBP in the micellar media increased compared to water by increasing solutionconcentration. Moreover, the non-ionic surfactant Brij-35 in lower concentrations than ionic surfactants CTAB andSDS can solve the drug ibuprofen better. This behaviour is a consequence of the interactions between the drug and themicelles under study.

Keywords:

Ibuprofen , Solubility , Micellar effect , Aqueous media