Effect of KCl on Volumetric Properties of Aqueous Solutions of Guaifenesin Drug

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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ISPTC21_265

تاریخ نمایه سازی: 30 دی 1397

Abstract:

In pharmacology, treatment, prevention and diagnosis a disease or promotion of healthmake by a chemicals called a pharmaceutical drug or medicine. Guaifenesin drug (GG) is used tocontrol cough and is sometimes combined with dextromethorphan, an antitussive (coughmedicine)[1]. The bioavailability and stability of a drug can be affected from the interactions withdifferent chemicals[2]. Therefore, in this work, density data of GG drug in water and aqueoussolutions of KCl have been measured within KCl molality range of (0.05, 0.1, and 0.15) mol kg-1at T = (298.15, 308.15 and 318.15) K. The apparent molar volume (V(ϕ) have been calculatedfrom density values with equation of (...); in which m is molality of solution, M isthe molar mass of the GG drug, d and d0 are densities of solution and solvent, respectively. Thebehaviours of apparent molar volume for aqueous solution of GG and also GG + KCl indicates adecrease in the interaction of GG-H2O, as well as GG-KCl-H2O with temperature increasing.The (V(ϕ)) values for the aqueous solutions containing drug and also KCl are higher than those ofthe aqueous solutions containing the drug and increase with increasing the concentration of salt.This behavior suggests that the size of the GG molecule increases due to the decrease in theinteraction of GG with water in the presence of salt. The apparent molar volume values of theconsidered solutions have successfully been modelled via the Redlich–Meyer type equation[3] inthe dilute region.

Authors

Maryam Ghadimi-Kaljahi

Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Roghayeh Majdan-Cegincara(Saghinsara)

Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran