A review on electrospun wound dressings
Publish place: 1st International Iranian Tissue Engineering and Regenerative Medicine Congress (ITERM2018)
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ITERMED01_215
تاریخ نمایه سازی: 7 مرداد 1398
Abstract:
Wound dressings have experienced tremendous changes since the ancient times. The development starts with the use of passive materials to simply cover the wounds to the dressings of the present time that can actively interact with wounded tissue to exhibit various extraordinary functions. Among fabrication methods, electrospinning has gained therapeutic appeal, over the past decade. The inherently high surface to volume ratio of electrospun scaffolds can enhance cell attachment and drug loading efficiency. Various materials can be electrospun including: biodegradable, non-degradable, and natural materials. Electrospinning parameters can be tailored giving control over both the bulk mechanical properties and the biological response to the scaffold. The modern wound care materials, made of electrospun biopolymers, may contain various therapeutic agents such as antioxidant, growth factors, antibacterial, and anti- inflammatory agents, which could be slowly released to the wounded tissue promoting the healing process. These scaffolds have structural similarity to native extracellular matrix with the size of fibers ranging from tens of nanometers to micrometers. With the right choices of biomaterials used for the fabrication of matrices, they could exhibit significantly higher healing potential compared with the conventional fibrous dressing materials, such as sterile gauze.
Keywords:
Authors
Saeed Farzamfar
Department of tissue engineering and applied cell sciences, school of advanced technologies in medicine, Tehran University of Medical Sciences, Tehran, Iran
Majid Salehi
Department of tissue engineering and applied cell sciences, school of medicine, Shahroud University of Medical sciences, Tehran, Iran
Jafar Ai
Department of tissue engineering and applied cell sciences, school of advanced technologies in medicine, Tehran University of Medical Sciences, Tehran, Iran