Poly (2-Hydroxyethyl Methacrylate)-based molecularly imprinted polymer nanoparticles: synthesis and β-sitosterol release

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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ITERMED01_380

تاریخ نمایه سازی: 7 مرداد 1398

Abstract:

Cardiovascular diseases (CVD) have been remained the main cause of mortality worldwide. High total cholesterol and low lipoprotein cholesterol (LDL-C) concentrations in the blood are major diet-related risk factors for the development of CVD. Cholesterol level can be kept in the minimum level using drugs such as statins and ezetimibe. Although statins (e.g., mevastatin, lovastatin, cerivastatin and simvastatin) are effective drugs, unfortunately they are expensive and have severe side effects including muscular weakness and toxicity. In contrast, plant-derived sterols are effective on the reduction of serum cholesterol levels while including the regular diet. This work was aimed to synthesize and characterize poly (2-hydroxyethyl methacrylate) (PHEMA)-based molecularly imprinted polymer nanoparticles (MIP NPs) containing β-sitosterol via precipitation polymerization. The molecular structure of the MIP and also, non-imprinted polymer (NIP) NPs were compared by means of Fourier transform infrared (FTIR) spectroscopy. The morphological observations by using transmission electron microscopy (TEM) confirmed the formation of MIP NPs as small as 100 nm in average diameter through an appropriate synthesis conditions. Furthermore, the ultraviolet-visible (UV-vis) spectrophotometry results proved a controlled release of β-sitosterol from the MIP NP samples compared with NIP ones at the extended time periods. Therefore, PHEMA-based MIP NP samples were promising candidates for β-sitosterol delivery.

Authors

Parisa Mosafer

Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran, Iran.

Ghassem Amoabediny

Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran, Iran.

Payam Zahedi

Department of Polymer, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran