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Protective effect of Berberis vulgaris on Fenton reaction-induced DNA cleavage

Credit to Download: 1 | Page Numbers 8 | Abstract Views: 127
Year: 2019
COI code: JR_AJP-9-3_003
Paper Language: English

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Authors Protective effect of Berberis vulgaris on Fenton reaction-induced DNA cleavage

  Nooshin Sadat Asadi - Department of Biology, Faculty of Science, Yazd University, Yazd, Iran
  Mohammad Mehdi Heidari - Department of Biology, Faculty of Science, Yazd University, Yazd, Iran
  Mehri Khatami - Department of Biology, Faculty of Science, Yazd University, Yazd, Iran
  Vahideh Ghorani - Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract:

Objective: Berberis vulgaris contains antioxidants that can inhibit DNA cleavage. The purpose of this study was to evaluate the antioxidant and protective activity of B. vulgaris on DNA cleavage. Materials and Methods: In this study, the antioxidant capacity of B. vulgaris was investigated using DPPH and its protective effect was evaluated on pBR322 plasmid and lymphocyte genomic DNA cleavage induced by Fenton reaction, by DNA electrophoresis. Results: Aqueous extract of B. vulgaris presented dual behavior with a potent antioxidant activity at 0.25and 0.75mg/ml for pBR322 plasmid and lymphocyte genomic DNA, respectively, but a pro-oxidant activity was observed at higher concentrations. Conclusion: Our results indicated that B. vulgaris extract an inhibit Fenton reaction-induced DNA cleavage and oxidative cleavage of double-stranded DNA assay is a powerful technique that can be used to determine the antioxidant and pro-oxidant properties of a compound on cellular components such as DNA.

Keywords:

Antioxidant activity, Berberis vulgaris, DNA damage, Fenton reaction

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COI code: JR_AJP-9-3_003

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Asadi, Nooshin Sadat; Mohammad Mehdi Heidari; Mehri Khatami & Vahideh Ghorani, 2019, Protective effect of Berberis vulgaris on Fenton reaction-induced DNA cleavage, Avicenna Journal of Phytomedicine 9 (3), https://www.civilica.com/Paper-JR_AJP-JR_AJP-9-3_003.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Asadi, Nooshin Sadat; Mohammad Mehdi Heidari; Mehri Khatami & Vahideh Ghorani, 2019)
Second and more: (Asadi; Heidari; Khatami & Ghorani, 2019)
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Type: state university
Paper No.: 11274
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