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Comparison of the Efficacy of Oral Simvastatin and Topical Simvastatin Solution in Decreasing Post-Laparotomy Adhesions in Rats

Credit to Download: 1 | Page Numbers 5 | Abstract Views: 41
Year: 2018
COI code: JR_AJS-5-1_008
Paper Language: English

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Authors Comparison of the Efficacy of Oral Simvastatin and Topical Simvastatin Solution in Decreasing Post-Laparotomy Adhesions in Rats

  Mojtaba Javaherzadeh - Associate Professor, Department of Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  Babak Sabet - Associate Professor, Department of Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  Mohammad Nejati - Resident, Department of Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ali Shekarchizadeh - Researcher, Poursina Hakim Gastrointestinal Research Center, Poursina Hakim Research Institution, Isfahan, Iran
  Abass Mirafsharieh - Associate Professor, Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  Mohammad Bayat - Professor, Department of Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract:

Background: Intra-abdominal adhesions and their complications occur frequently after laparotomy. The aim of this study was to compare oral versus intraperitoneal administration of simvastatin in decreasing post-laparotomy adhesions in rat.Methods: Thirty male Wistar albino rats were divided into three groups of ten. All the rats underwent laparotomy and induction of adhesions using the method of Meso-Stitch approximation of injured cecum and abdominal wall. One group received oral simvastatin (40 mg/kg) daily during two weeks before the laparotomy. In the two other groups, 2 ml of solution of simvastatin (40 mg/kg) or distilled water (as placebo) was spilled into abdomen before closing abdominal wall, respectively. After 14 days, all the rats were put under laparotomy again to be compared. Rates and grades of adhesions were assessed using Hoffman et al. and Lauder et al. Scale and histopathological reports.Results: In placebo group, the grade II and III adhesion was seen in 2 and 8 rats, respectively. In local simvastatin group, there was no adhesion in 5 rats, and grade I and II adhesion was seen in 3 and 2 rats, respectively. In oral simvastatin group, 6 rats were without adhesion, and 3 cases with grade I and 1 case with grade II adhesion. The frequency and grade of adhesion were statistically different in simvastatin groups compared to the placebo group (P < 0.001), but not with each other.Conclusions: Oral simvastatin for two weeks before the laparotomy can reduce post-laparotomy adhesion bands as well as local administration of simvastatin solution.

Keywords:

Abdomen; Surgical adhesions; Simvastatin; Laparotomy

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Javaherzadeh, Mojtaba; Babak Sabet; Mohammad Nejati; Ali Shekarchizadeh; Abass Mirafsharieh & Mohammad Bayat, 2018, Comparison of the Efficacy of Oral Simvastatin and Topical Simvastatin Solution in Decreasing Post-Laparotomy Adhesions in Rats, Academic Journal of Surgery 5 (1), https://www.civilica.com/Paper-JR_AJS-JR_AJS-5-1_008.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Javaherzadeh, Mojtaba; Babak Sabet; Mohammad Nejati; Ali Shekarchizadeh; Abass Mirafsharieh & Mohammad Bayat, 2018)
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