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Anticonvulsant Drugs and Severe Adverse Cutaneous Drug Reactions: A Longitudinal Observational Study

Credit to Download: 1 | Page Numbers 6 | Abstract Views: 60
Year: 2019
COI code: JR_CJNS-5-3_004
Paper Language: English

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Authors Anticonvulsant Drugs and Severe Adverse Cutaneous Drug Reactions: A Longitudinal Observational Study

  Abbas Darjani - Skin Research Center, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran.Skin Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran
  Narges Alizadeh - Skin Research Center, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
  Hossein Abdi - Skin Research Center, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
  Maryam Hosseini - Skin Research Center, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
  Shirin Zaresharifi - Skin Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran

Abstract:

Background: Severe Adverse Cutaneous Reactions to Drugs (SACRDs) are skin eruptions due to drugs, which can cause morbidity and morbidity in patients. Objectives: The aim of this study was to determine the offending drug/agents and clinical phenotypes of SACRDs leading to admissions to the hospital. Materials & Methods: We conducted a retrospective cross-sectional study during one year (March 2012-2013) on patients admitted to the department of Dermatology at Razi Hospital of Rasht, Iran. First, the clinical and drug history of all patients were collected. Then, two dermatologists examined them and diagnosed drug eruptions according to the clinical types of adverse drug reactions included in the study. Collected data were analyzed in SPSS V. 18 software by using Chi-squared test, Fisher s Exact test, and one-way ANOVA. The significancelevel was set at p<0.05. Results: Forty-six patients were diagnosed with SACRDs. The most common SACRDs were toxic epidermal necrolysis/stevens Johnson syndrome (TEM/SJS) and Drug Reaction with eosinophilia and systemic symptom syndrome (DRESS) syndrome (30.5% and 2.1%, respectively). The most common culprit drugs were anticonvulsants (43.5%) and antibiotics (26.1%). Peripheral blood eosinophilia was observed in 30.4% of patients. Conclusion: Anticonvulsants were the most common cause of ACDRs, leading to the hospitalization of the patients.

Keywords:

Drug eruptions; Anticonvulsants; Skin

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COI code: JR_CJNS-5-3_004

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Darjani, Abbas; Narges Alizadeh; Hossein Abdi; Maryam Hosseini & Shirin Zaresharifi, 2019, Anticonvulsant Drugs and Severe Adverse Cutaneous Drug Reactions: A Longitudinal Observational Study, Caspian Journal of Neurological Sciences 5 (3), https://www.civilica.com/Paper-JR_CJNS-JR_CJNS-5-3_004.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Darjani, Abbas; Narges Alizadeh; Hossein Abdi; Maryam Hosseini & Shirin Zaresharifi, 2019)
Second and more: (Darjani; Alizadeh; Abdi; Hosseini & Zaresharifi, 2019)
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