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Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review

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Year: 2019
COI code: JR_IJBMS-22-4_001
Paper Language: English

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Authors Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review

  Majid Zeinali - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran|Social Security Organization, Mashhad, Islamic Republic of Iran
  Mohammad Reza Zirak - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran
  Seyed Abdolrahim Rezaee - Inflammation and Inflammatory Diseases Research Center, Mashhad University of Medical Science, Mashhad, Islamic Republic of Iran
  Gholamreza Karimi - Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic

Abstract:

The medicinal uses of saffron, the dried stigmas of Crocus sativus L., have very long history in food coloring agent, and flavoring agent as well as traditional medicine for the treatment of several diseases. Crocus sativus is rich in carotenoids that affect immunity. This review summarizes the putative immunoregulatory effects of saffron and its active its derivatives including crocin, crocetin and safranal. In modern studies, its active constituents including protective effects, anti-inflammatory activities and molecular mechanisms of saffron on the immune system have been demonstrated. Furthermore, the beneficial effects of saffron on inhibition of serum levels nuclear transcription factor κB (NF-κB) p65 unit, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ) and some interleukin (IL) such as IL-1β, IL-6, IL-12, IL-17A were reported. Furthermore, saffron has been known as the antagonist of NF-κB and the agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). In addition, saffron down-regulates the key pro-inflammatory enzymes such as myeloperoxidase (MPO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), phospholipase A2, and prostanoids.This review summarizes the protective roles of C. sativus and its constituents against the pathogenesis of immune diseases and understanding a better management of these problems. Taken together, the main bioactive constituents of saffron may have health-promoting with important benefits in immune-related disorders. Finally, our study indicates that these bioactive constituents can affect both cellular and humoral immunity functions.

Keywords:

Anti-inflammatory, Crocus sativus, Cytokines, Immunomodulatory, Saffron

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COI code: JR_IJBMS-22-4_001

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Zeinali, Majid; Mohammad Reza Zirak; Seyed Abdolrahim Rezaee & Gholamreza Karimi, 2019, Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review, Iranian Journal of Basic Medical Sciences 22 (4), https://www.civilica.com/Paper-JR_IJBMS-JR_IJBMS-22-4_001.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Zeinali, Majid; Mohammad Reza Zirak; Seyed Abdolrahim Rezaee & Gholamreza Karimi, 2019)
Second and more: (Zeinali; Zirak; Rezaee & Karimi, 2019)
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Type: Medical University
Paper No.: 5704
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