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Acute Myeloid Leukemia as the Main Cause of Pancytopenia in Iranian Population

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Year: 2017
COI code: JR_IJP-12-3_011
Paper Language: English

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Authors Acute Myeloid Leukemia as the Main Cause of Pancytopenia in Iranian Population

  Hasan Jalaeikhoo - AJA Cancer Research Center (ACRC), AJA University of Medical Sciences, Tehran, Iran
  Seyed Mohammad Hossein Kashfi - Gastroenterology and Liver Diseases Research center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  Pedram Azimzadeh - Gastroenterology and Liver Diseases Research center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  Ahmad Narimani - AJA Cancer Research Center (ACRC), AJA University of Medical Sciences, Tehran, Iran

Abstract:

Background & objective: Pancytopenia is the reduction in the number of all 3 major cellular elements of blood and leads to anemia, leukopenia, and thrombocytopenia. A wide variety of etiologies result in pancytopenia including leukemia, aplastic anemia, and megaloblastic anemia. The current study identified the different etiologies of pancytopenia based on bone marrow examination in Iranian patients with pancytopenia. Methods: A total of 683 cases of pancytopenia with various etiologies were selected for this retrospective study. Bone marrow biopsy was performed with the standard technique using Jamshidi needle. The inclusion criteria for patients with pancytopenia were hemoglobin (Hb) 9/L, and platelet count 9/L. Results: In the present study acute leukemia was the first most common etiology detected in 235 (35.4%) patients in which acute myeloid leukemia (AML) comprised the majority of cases 142 (21.4%), followed by myelodysplastic syndrome (MDS) 100 (15%). In patients less than 20 years old, acute leukemia was also the commonest cause identified in 56 (57.7%) cases in which acute lymphoblastic leukemia (ALL) with 38.7% was the most common etiology; however in adults (> 45 year old), AML accounted for the majority of cases 76 (53.5%). Conclusion: Since acute leukemia was the commonest etiology in both young and adults in which AML accounted for the majority of cases with pancytopenia in Iranian population, there was an urgent need to identify the underlying molecular or genetic mechanism of this malignancy for better further medical management and patients survival.

Keywords:

Pancytopenia, Acute Leukemia, Myelodysplastic Syndrome, AML

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COI code: JR_IJP-12-3_011

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Jalaeikhoo, Hasan; Seyed Mohammad Hossein Kashfi; Pedram Azimzadeh & Ahmad Narimani, 2017, Acute Myeloid Leukemia as the Main Cause of Pancytopenia in Iranian Population, IRANIAN JOURNAL of PATHOLOGY 12 (3), https://www.civilica.com/Paper-JR_IJP-JR_IJP-12-3_011.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Jalaeikhoo, Hasan; Seyed Mohammad Hossein Kashfi; Pedram Azimzadeh & Ahmad Narimani, 2017)
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Type: Medical University
Paper No.: 656
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