CIVILICA We Respect the Science
Publisher of Iranian Journals and Conference Proceedings

MiR-21 Expression in Wilms’ Tumor

Credit to Download: 1 | Page Numbers 7 | Abstract Views: 75
Year: 2018
COI code: JR_IJP-13-4_006
Paper Language: English

How to Download This Paper

For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.

Authors MiR-21 Expression in Wilms’ Tumor

  Navid Bazzaz - Tehran university of medical sciences, Tehran, Iran
  Nazila Nouraee Nouraee - Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran, Department of Experimental Therapeutics, MD Anderson Cancer Center, University of Texas, Houston, Texas,
Ali Zare-Mirzaie - Fellow of molecular pathology and cytogenetic, Tehran University Medical Sciences, Tehran, Iran. Associate professor of pathology, Iran University Medical Sciences, Tehran, Iran
Seyed Javad Mowla Mowla - Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University,Tehran, Iran


Background and Objective: Wilms’ tumor (WT) is the most common genitourinary tract tumor in children. MicroRNAs (miRNAs) are small non-coding RNAs; their role in the pathogenesis of many types of human cancers has been identified. We aimed to evaluate the expression of miR-21, a well-known oncomir, in WT tissue samples which is a very common urinary tract malignancy in children. Methods: We performed chromogenic in situ hybridization (CISH) to detect the sub-cellular localization of miR-21 in 25 formalin-fixed, paraffin-embedded (FFPE) samples of WT. We also evaluated miR-21 expression in 24 of these blocks and 6 normal kidneys as controls using quantitative real-time PCR technique. Results: While our real-time PCR analysis showed miR-21 significant overexpression in 4 tumors compared to the normal kidney samples, we could not detect significant ISH signal in any of these samples. Conclusion: Low expression of miR-21 in WT might pinpoint the weak involvement of this miRNA in the pathogenesis of this cancer.


Wilms’ tumor, miR-21, CISH, Real-time PCR

Perma Link
COI code: JR_IJP-13-4_006

how to cite to this paper:

If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Bazzaz, Navid; Nazila Nouraee Nouraee; Ali Zare-Mirzaie & Seyed Javad Mowla Mowla, 2018, MiR-21 Expression in Wilms’ Tumor, IRANIAN JOURNAL of PATHOLOGY 13 (4), the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Bazzaz, Navid; Nazila Nouraee Nouraee; Ali Zare-Mirzaie & Seyed Javad Mowla Mowla, 2018)
Second and more: (Bazzaz; Nouraee; Zare-Mirzaie & Mowla, 2018)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)


The University/Research Center Information:
Type: Medical University
Paper No.: 6459
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.

Research Info Management

Export Citation info of this paper to research management softwares

New Related Papers

Iran Scientific Advertisment Netword

Share this paper


COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.