Comparison of salivary IgA, tear IgA and serum IgE in patients suffering from chronic rhinosinusitis

Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_INTJMI-1-1_004

تاریخ نمایه سازی: 15 مهر 1398

Abstract:

Objective; Chronic rhinosinusitis is one ofthe most common inflammatory diseasesaround the world which imposes two percentof the world population. Studying the impactof chronic inflammation on immunoglobulinproduction is a subject of differentinvestigations. This study conducted toevaluate the effect of chronic inflammationon secretory immunoglobulin productionand allergic reaction. Therefore, in thecurrent research, we compared salivary IgA,tear IgA and serum total IgE levels ofpatients suffered from chronic rhinosinusitiswith normal subjects to reveal the upregulation of these immunoglobulins inchronically inflamed mucosa.Patients and Method; we monitoredimmunoglobulins levels of 28 participantsincluding 14 patients with chronicrhinosinusitis and 14 normal control whichassayed by Elisa for total IgE and directimmunoenzymatic determination forsalivary IgA and tear IgA.Result; there were no significant changes inthese immunoglobulin levels as compared tocontrols. P value of salivary IgA was 0.963,for tear IgA, it was P=0.862 and for serumIgE became P=0.068.Conclusion; Our study indicated thatallergic reaction and mucosal immunitymediated by salivary, lacrimal IgA andserum IgE didn’t play an important role inchronic inflammation.

Authors

Seyyed Abbas Hashemi

Medical Student, Faculty of medicine, Student Research committee, Mazandaran university of medical sciences, Sari IRAN

Saeid Abediankenari

Microbiology and Immunology department, Faculty of Medicine, Mazandaran university of medical sciences, Sari IRAN

Seyyed Abdollah Madani

ENT department, Faculty of Medicine, traditional and complementary medicine research center, Mazandaran university of medicalsciences, Sari IRAN

Mohammad Akbari

Microbiology and Immunology department, Faculty of Medicine, Mazandaran university of medical sciences, Sari IRAN