Antibacterial activity of nickel and nickel hydroxide nanoparticles against multidrug resistance K. pneumonia and E. coli isolated urinary tract
Publish place: Nanomedicine Journal، Vol: 5، Issue: 1
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_NAMJ-5-1_004
تاریخ نمایه سازی: 18 تیر 1398
Abstract:
Objective(s): Antibacterial materials are so significant in the textile industry, water disinfection, medicine,
and food packaging. Unfortunately, organic compounds for sterilization show toxicity to the human body;
therefore, the interest in inorganic disinfectants such as metal oxide nanoparticles (NPs) is increasing.
Materials and Methods: Nickel and nickel hydroxide nanoparticles (NiNPs and Ni(OH)2-NPs) were
prepared and characterized by DLS, SEM, AFM and ATR. Antibacterial activity assay was carried by Spot on
lawn method against two selected standard pathogenic bacteria such as E. coli (as Gram negative), S. aureus
(as Gram positive) and multidrug resistance K. pneumonia and E. coli.
Also the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were
determined against two selected standard pathogenic bacteria and multidrug resistance K. pneumonia and
E. coli.
Results: The formation of the NiNPs and Ni(OH)2-NPs were confirmed by DLS, SEM, AFM and ATR.
Antibacterial activity of nanoparticles were confirmed against two selected standard pathogenic bacteria
such as E. coli and S. aureus. And also, NiNPs and Ni(OH)2-NPs revealed fair antibacterial effect against
multidrug resistance K. pneumonia and E. coli based on MIC and MBC data. As well, the experimental data
presented that the antibacterial activity of NiNPs was more than Ni(OH)2-NPs.
Conclusion: Based on the achieved results, NiNPs and Ni(OH)2-NPs show antibacterial activity against
clinical patients bacteria (multidrug resistance K. pneumonia and E. coli(. Finally, the NPs evaluated in
this study have promising properties for applications as antiseptic agent for environment; however, further
studies are warranted such as study toxicity NPs on normal human cell line and other clinical bacteria.
Keywords:
Authors
Mahboubeh Mirhosseini
Department of Biology, Payame Noor University, Iran
Bahareh Kheiri Hafshejani
Department of Biology, Payame Noor University, Iran
Fariba Dashtestani
Department of Biology, Electronic Branch, Islamic Azad University, Tehran, Iran
Fatemeh Hakimian
Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
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