Is there any association between human T-lymphotropic virus type 1 (HTLV-1) infection and Behcet’s disease
Publish place: Rheumatology Research، Vol: 3، Issue: 4
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RHRE-3-4_002
تاریخ نمایه سازی: 1 خرداد 1398
Abstract:
Both human T-cell lymphotropic virus type 1 (HTLV-1) infection and Behcet’s disease (BD) are common to a similar geographic area. Furthermore, some clinical presentations of BD and HTLV-1 infection, such as ocular lesions and neurologic involvement, are the same. The aim of this study was to assess a possible association between BD and HTLV-1 infection.In this case-control study, the HTLV-1 infection frequency in BD patients was compared with that for the general population. The case group consisted of 68 patients with a definite diagnosis of BD who referred to a research center at Mashhad University of Medical Sciences in Mashhad, Iran. The control group consisted of 210 healthy individuals selected from the general population of Mashhad. The presence of HTLV antibodies in the sera was assessed using enzyme-linked immunosorbent assay and the seroreactive samples were confirmed by polymerase chain reaction.HTLV-1 infection was detected in 4.41% (3/68) and 1.43% (3/210) of cases and controls, respectively; however, the difference was not statistically significant (P value = 0.16).The prevalence of HTLV1 infection in patients with BD was three-fold higher than in the general population, which suggests an association between these two conditions.
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Authors
Mohammad Javad Yazdanpanah
Cutaneous Leishmaniasis Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Reza Hedayati-Moghaddam
Blood Borne Infections Research Center, Academic Center for Education, Culture & Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran
Maryam Sahebari
Rheumatic Diseases Research Center (RDRC), School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud Mahmoudi
Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
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