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THE EFFECT OF CANNABIS SATIVA ON BRAIN TISSUE IN RAT: BEHAVIORAL AND HISTOLOGICAL CHANGES

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Year: 2019
COI code: KAMED13_142
Paper Language: English

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Authors THE EFFECT OF CANNABIS SATIVA ON BRAIN TISSUE IN RAT: BEHAVIORAL AND HISTOLOGICAL CHANGES

  Farshid Parsa - Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
  Seyed Ebrahim Hoseini - Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
  Davood Mehrabani - Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  Seyedeh Sara Hashemi - Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  Amin Derakhshanfar - Diagnostic Laboratory Sciences andTechnology Research center,School of Paramedical Sciences,Shiraz University of Medical Sciences,Shiraz,Iran 2.Center of Comparative and Experimental Medicine,Shiraz University of Medical Sciences,Shiraz,Iran

Abstract:

Background and Aim : Cannabis has been used by humans for thousands of years for medical, spiritual and recreational purposes. It has amnestic, anxiogenic and psychotomimetic effects. So this study was undertaken to assess histological changes in brain tissue and behavioral modifications following Cannabis sativa use. Methods : fifty-four Wistar rats were randomly allocated to 9 equal groups of 6. The experimental group received cannabis subcutaneously (2 mg/kg, 0.5 mL/rat) at 12 hours intervals, for 2 weeks, and the sham group received ethanol (0.5 mL/rat) and the control group received normal saline (0.5 mL/rat), identically. Histological assessment was done 7, 14 and 21-days after interventions. An elevated plus-maze (EPM) evaluated the animals’ behavior using ODLog program and the nociceptive sensitivity was determined by Plantar test. Results : Regarding the effect of cannabis on mean percentage of alternation behavior at the end of the first, second and third week, a significant difference was noted between the experimental and the control group showing that cannabis significantly reduced the spatial memory of the experimental group. Comparison of the effect of cannabis on the mean number of arms the entered rats at the end of the third week between the experimental and the control group, a significant difference was visible.Conclusion : The consumption of cannabis leads to serious damages to the brain tissue of the rats in both the cerebrum and meninges. According to our findings, the consumption of cannabis extracts had a significant effect on the spatial memory of the rats and leads to a serious reduction and disruption of the spatial memory. Hence, we concluded that spatial memory reduction as well as the brain tissue damage is mainly related to the consumption of cannabis.

Keywords:

Behavior, Histology, Nervous system, Brain, Cannabis sativa

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Parsa, Farshid; Seyed Ebrahim Hoseini; Davood Mehrabani; Seyedeh Sara Hashemi & Amin Derakhshanfar, 2019, THE EFFECT OF CANNABIS SATIVA ON BRAIN TISSUE IN RAT: BEHAVIORAL AND HISTOLOGICAL CHANGES, 13th annual international addiction science congress, تهران, مركز تحقيقات سلولي و مولكولي دانشگاه علوم پزشكي ايران, https://www.civilica.com/Paper-KAMED13-KAMED13_142.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Parsa, Farshid; Seyed Ebrahim Hoseini; Davood Mehrabani; Seyedeh Sara Hashemi & Amin Derakhshanfar, 2019)
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Type: Azad University
Paper No.: 6070
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