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THE EFFECT OF METHAMPHETAMINE USE ON BRAIN TISSUE IN RAT MODEL: BEHAVIORAL AND HISTOLOGICAL CHANGES

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Year: 2019
COI code: KAMED13_182
Paper Language: English

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Authors THE EFFECT OF METHAMPHETAMINE USE ON BRAIN TISSUE IN RAT MODEL: BEHAVIORAL AND HISTOLOGICAL CHANGES

  Somayeh Rostam khani - Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
  Seyed Ebrahim Hoseini - Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
  Davood Mehrabani - Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 4.Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 5.Center of Comparative and Experimental Medicine, Shiraz University of
  Seyedeh Sara Hashemi - Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  Amin Derakhshanfar - Center of Comparative and Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract:

Background and Aim : Methamphetamine (METH) is a highly abused psychostimulant, while the study of cerebral injuries caused by neurotoxic effects of abused METH seems necessary. So this study examined the effect of METH on brain tissue by assessing behavioral and histological changes in experimental rat.Methods : Wistar rats (n=30) were randomly divided to two equal groups. The experimental group received METH subcutaneously (2 mg/kg, 0.5 mL/rat) at 12 hours intervals, for 2 weeks, and the control group received normal saline identically (0.5 mL/rat). Histological evaluation was done after 1, 2 and 3 weeks post-interventions. Using an elevated plus-maze (EPM), the animals’ behavior was evaluated by ODLog program and the nociceptive sensitivity was assessed by Plantar testResults : One week after METH use in cerebrum, macrogliosis was visible and after 2 weeks, changes as dysmyelination and after 3 weeks, leukoencephalomalacia and laminar necrosis. In meninges after 2 weeks, vasodilation, hyperemia, and hemorrhage were visible in the tissue. Regarding behavioral changes and METH effect on mean percentage of behavioral alterations at the end of the first, second and third week, METH use could significantly reduce the spatial memory in experimental group, but when the effect of METH on the mean number of arms of the entered rats was evaluated at the end of the first, second and third week, no significant effect was visible after METH use in the experimental group.Conclusion : Histological changes after METH use in the cerebrum revealed macrogliosis, dysmyelination leukoencephalomalacia and laminar necrosis. These changes in meninges were vasodilation, hyperemia, and hemorrhage. Regarding METH effect on mean percentage of behavioral alterations, METH use significantly reduced the spatial memory in experimental group.

Keywords:

Behavior, Histology, Nervous system, Brain, Methamphetamine

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COI code: KAMED13_182

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Rostam khani, Somayeh; Seyed Ebrahim Hoseini; Davood Mehrabani; Seyedeh Sara Hashemi & Amin Derakhshanfar, 2019, THE EFFECT OF METHAMPHETAMINE USE ON BRAIN TISSUE IN RAT MODEL: BEHAVIORAL AND HISTOLOGICAL CHANGES, 13th annual international addiction science congress, تهران, مركز تحقيقات سلولي و مولكولي دانشگاه علوم پزشكي ايران, https://www.civilica.com/Paper-KAMED13-KAMED13_182.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Rostam khani, Somayeh; Seyed Ebrahim Hoseini; Davood Mehrabani; Seyedeh Sara Hashemi & Amin Derakhshanfar, 2019)
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Type: Azad University
Paper No.: 6070
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