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SURVEYING THE EFFECT OF BUPROPION ON RELAPSE TO METHAMPHETAMINE DEPENDENCE INDUCED BY DEPRESSION IN RAT

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Year: 2019
COI code: KAMED13_336
Paper Language: English

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Authors SURVEYING THE EFFECT OF BUPROPION ON RELAPSE TO METHAMPHETAMINE DEPENDENCE INDUCED BY DEPRESSION IN RAT

  Fatemeh Hajipour - Pharmacognosy research center, School of Pharmacy ,Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  Alireza Malayeri - Department of Pharmacology ,School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract:

Background and Aim : Methamphetamine is a highly potent, addictive drug that is widely abused in many countries around the world. methamphetamine produces a general state of well-being along with increased wakefulness, talkativeness, and physical activity and decreased appetite. Behavioral treatment programs have had some success in the treatment of methamphetamine addiction, yet many patients continue to relapse after repeatedly seeking treatment. Thus, pharmacotherapies treatments for methamphetamine addiction are being evaluated. Bupropion is an atypical antidepressant with stimulant properties. This drug has been used off-label to treat methamphetamine addicts, thus prompting the need for systematic investigations of its efficacy Methods : male wister rats weighing 300-250 g in 5 groups were habituated and conditioned with metamphetamin (1 mg/kg, S.C., for 5 days). After that, primary forced swimming and conditioned place preference (CPP) were tested. They were followed by bupropion (2.5 mg/kg/day, Sc., for 5 days) administration. Finally same tests were performed. Administration of bupropion resulted in a decrement in final preference scores associated with a prime metamphetamine injection (PMI) compared to the primary scores Results : In a swimming test, bupropion increased the amount of final floating and decreased final activity scores compared with the primary scores.Conclusion : Several questions remain about bupropion’s impact during withdrawal, abstinence, and relapse in a preclinical setting. Research investigating these aspects of addiction will help provide a clearer picture on the effects of bupropion on methamphetamine administration in laboratory animals and methamphetamine abuse in humans

Keywords:

methamphetamine; bupropion; cpp; subject-rated drug effects; physiological drug effects

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Hajipour, Fatemeh & Alireza Malayeri, 2019, SURVEYING THE EFFECT OF BUPROPION ON RELAPSE TO METHAMPHETAMINE DEPENDENCE INDUCED BY DEPRESSION IN RAT, 13th annual international addiction science congress, تهران, مركز تحقيقات سلولي و مولكولي دانشگاه علوم پزشكي ايران, https://www.civilica.com/Paper-KAMED13-KAMED13_336.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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Type: Medical University
Paper No.: 2442
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