Published in: 5th Congress of Medical Bacteriology
COI code: MBMED05_017
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors Relationship between H. pylori eradication failure and difference in antibiotic resistance and therapeutic regimens: A one year follow upSaeed Bayati - Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Masoud Alebouyeh - Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, ShahidBeheshti University of Medical Sciences, Tehran, Iran
Nasser Ebrahimi Daryani - Department of Gastroenterology and Hepatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Reza Zali - Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Science, Tehran, Iran
Abstract:Background: Eradication failure of Helicobacter pylori infection could play a causal role in progression of gastric disorders. Methods: Accordingly, overall changes of resistance and minimal inhibitory concentration (MIC) of H. pylori strains to metronidazole, clarithromycin, and ciprofloxacin were studied in adult patients at two phases during 1 year period. Furthermore, association of therapeutic regimens with the refractory infection, changes of MIC values, and progression of histopathological changes were analyzed. Results: Among the infected patients at early phase of the study (32.3%), persistent infection with H. pylori was confirmed in 14 patients (56%) at the second phase. The results showed progression of the disease based on the histopathotological or endoscopic findings. A difference between primary and secondary resistance rates to clarithromycin (49% vs64.3%), metronidazole (76.36% vs100%), and ciprofloxacin (45% vs57.1%) was detected. Two fold increases in MIC50 values of clarithromycin and ciprofloxacin was detected at the second phase. Patients with intestinal metaplasia showed significantly higher resistance rates to all antibiotics. While ciprofloxacin-based regimens were more successful, failure of metronidazole based regimens was detected in 77% of the patients. Conclusion: Collectively, these results showed adverse effect of inappropriate medication on refractoryH. Pylori infection with a rise in resistance levels to antibiotics, resulting in progression of pathological disorders.
Keywords:Helicobacter pylori, Eradication failure, Antimicrobial resistance, Therapeutic regimens, Pathological changes
COI code: MBMED05_017
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Bayati, Saeed; Masoud Alebouyeh; Nasser Ebrahimi Daryani & Mohammad Reza Zali, 2018, Relationship between H. pylori eradication failure and difference in antibiotic resistance and therapeutic regimens: A one year follow up, 5th Congress of Medical Bacteriology, مراغه, دانشكده علوم پزشكي مراغه - انجمن علمي باكتري شناسي پزشكي ايران, https://www.civilica.com/Paper-MBMED05-MBMED05_017.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Bayati, Saeed; Masoud Alebouyeh; Nasser Ebrahimi Daryani & Mohammad Reza Zali, 2018)
Second and more: (Bayati; Alebouyeh; Ebrahimi Daryani & Zali, 2018)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
The University/Research Center Information:
Type: Medical University
Paper No.: 3023
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.
Research Info Management
Export Citation info of this paper to research management softwares
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.