Clinical and microbiological predictors of post prostate biopsy infection
Publish place: 5th Congress of Medical Bacteriology
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
MBMED05_021
تاریخ نمایه سازی: 1 دی 1397
Abstract:
Background: To research on clinical and bacterial risk factors and their relationship with post-prostate biopsy infection (PBI). Methods: In this prospective cohort study, rectal swabs were collected from 158 men prior to prostate biopsy and cultured selectively for identify ciprofloxacin-resistant (FQ-R) gram-negative bacteria. The patient characteristics, phylogenetic background, sequence typing and pulsed field gel electrophoresis (PFGE) pattern were compared in two groups of FQ-R E. coli rectal and clinical isolates. Results: In total, 73 (46.2%) patients had a positive rectal culture for FQ-R gram-negative bacteria (95.9% E. coli). PBI was observed in 20 (12.5%) cases; nearly all of these subjects were FQ-R-colonized. (17/73 [24%] vs. 3/85 [3.5%]; P<0.001). FQ-R colonization, diabetes, hospitalization and UTI were independent risk factors that increased the rate of PBI (All P<0.05). Despite the increase in infections among patients colonized with strains of E. coli ST131, its prevalence was almost statistically significant between colonized and infected groups[OR:3.269, 95% CI:0.942-11.448;P =.06].The PFGE patterns and antimicrobial susceptibility profiles of rectal and clinical isolates in 13 patients were similar which is remarkably important and informative. Conclusions: The most PBIs originate from FQ-R E. Coli rectal colonization. Rectal culture screening and assessment of clinical risk factors can predict the incidence of PBI in patients.
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Authors
Amir Hasanzadeh
Department of Microbiology, MaraghehUniversity of Medical Sciences, Maragheh, Iran
Mohammad Reza Pourmand
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Peter Black
Vancouver Prostate Centre, University of British Columbia, Vancouver, B.C., Canada
Gholamreza pourmand
Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran