Antimicrobial resistance of uropathogenic Escherichia coli strains Isolated from Imam Khomeini Hospital, Sarab-Iran

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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MBMED05_087

تاریخ نمایه سازی: 1 دی 1397

Abstract:

Background: UropathogenicEscherichia coli (UPEC) is one of the most important etiologic agent of urinary tract infection (UTI). The aim of this study was to investigate the antibiotic resistance of UPEC isolates isolated from patients admitted to SarabImam Khomeini Hospital. Methods: Our study was carried out in the Imam Khomeini Teaching Hospital of SarabFaculty of Medical Sciences. Sample collection was done between March 2017 and November 2017, 117 urine samples were collected and cultured, antimicrobial susceptibility tests were done by disk diffusion method.All microbiological procedures were carried out in central laboratory of Sarab Faculty of Medical Sciences.All samples were incubated at 37°C for 24 h until adequate growth was present. E. coli-positive strains were subjected to disk diffusion methods. Results were analyzed after using ten commonly used antibiotics for susceptibility test according to CLSI protocol. Results: From 117 urine samples, 92uropathogenicE.coli strains were isolated. Antimicrobial sensitivity tests showed that all isolates were resistance to at least one antibiotic and also 83% of isolates were multi-resistant. Antibiotic Resistance was %8 to amikacin, %19 to gentamicin, %34 to ciprofloxacin, %65 to nalidixic acid, and %10 to nitrofurantoin. Conclusion: The increasing prevalence of infections caused by antibiotic-resistant bacteria makes the empirical treatment of UTIs more difficult. One of the important factors contributing to these high resistance rates might be high antibiotic use. In conclusion, we identified a large number of the UPEC strains with low levels of resistance against several groups of antibiotics with respect to the high prevalence of antibiotic resistance genes. Monitoring antibiotic prescription and resistance patterns in the patients admitted to Imam Khomeini Hospital may serve as an early indicator of changes in the antibiotic susceptibility of clinical isolates. The antibiotic resistance profiling of UPEC strains elucidates that the antimicrobial agents such as chloramphenicol, cefoxitin, cefepime, ceftazidime might still be used in the therapy for treating UTIs.

Authors

A Bahadori

Department of Medical Microbiology, Sarab Faculty of Medical Sciences, Sarab-Iran

Kh Maleki Chollou

Department of Nursing, Sarab Faculty of Medical Sciences, Sarab, Iran

A Sadighi

B.Sc. student of Medical Laboratory Sciences, Sarab Faculty of medical sciences, Sarab, Iran

L Hasheminejad

B.Sc. student of Nursing, Sarab Faculty of medical sciences, Sarab, Iran