Prevalence of plasmid-mediated quinolone resistancegenes among Escherichia coliisolated from urinary tract infectionsin Tabriz
Publish place: 5th Congress of Medical Bacteriology
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
MBMED05_100
تاریخ نمایه سازی: 1 دی 1397
Abstract:
Background: The aim of this study was to investigate the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants among E. coli isolated from urinary tract infections from Tabriz. Methods: A total of 92 E. coliisolated from UTIs were collected. Antimicrobialsusceptibility was determined by disc diffusion assay. The screening of qnrA, qnrB, qnrC, qnrD, qnrS, aac (6′)-Ib-cr, oqxA, oqxBand qepA genes were done by PCRamongfluoroquinolone-resistantE.coli isolates. Results: Of the 92 isolates, 75 (81.5%) was resistant to fluoroquinolone. Sixty-eightof the resistant isolates (90.7%) harbored at least one PMQR genes.The most common PMQR gene were aac (6′)-Ib-cr 59 (78.7%), follow by oqxB 27 (36%), oqxA 19 (25.3%), qnrB 18 (24%), qnrS 16 (21.3%), qnrD 7 (9.3%), qnrC 7 (9.3%),qnrA4 (5.3%), and qepA 3 (4 %). Conclusion: PMQR genes were highly predominant amongfluoroquinolone-resistant E.coli isolated from UTIs. The aac (6′)-Ib-cr was the most prevalent PMQR gene. Therefore, it is essential to monitor forthe spread of PMQR genes in clinicalE coli isolates.
Authors
Robab Azargun
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Hossein Soroush Barhaghi
Microbiology Department, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Hossein Samadi Kafil
Microbiology Department, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Reza Ghotaslou
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran