Prevalence of plasmid-mediated quinolone resistancegenes among Escherichia coliisolated from urinary tract infectionsin Tabriz

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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MBMED05_100

تاریخ نمایه سازی: 1 دی 1397

Abstract:

Background: The aim of this study was to investigate the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants among E. coli isolated from urinary tract infections from Tabriz. Methods: A total of 92 E. coliisolated from UTIs were collected. Antimicrobialsusceptibility was determined by disc diffusion assay. The screening of qnrA, qnrB, qnrC, qnrD, qnrS, aac (6′)-Ib-cr, oqxA, oqxBand qepA genes were done by PCRamongfluoroquinolone-resistantE.coli isolates. Results: Of the 92 isolates, 75 (81.5%) was resistant to fluoroquinolone. Sixty-eightof the resistant isolates (90.7%) harbored at least one PMQR genes.The most common PMQR gene were aac (6′)-Ib-cr 59 (78.7%), follow by oqxB 27 (36%), oqxA 19 (25.3%), qnrB 18 (24%), qnrS 16 (21.3%), qnrD 7 (9.3%), qnrC 7 (9.3%),qnrA4 (5.3%), and qepA 3 (4 %). Conclusion: PMQR genes were highly predominant amongfluoroquinolone-resistant E.coli isolated from UTIs. The aac (6′)-Ib-cr was the most prevalent PMQR gene. Therefore, it is essential to monitor forthe spread of PMQR genes in clinicalE coli isolates.

Authors

Robab Azargun

Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Mohammad Hossein Soroush Barhaghi

Microbiology Department, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Hossein Samadi Kafil

Microbiology Department, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Reza Ghotaslou

Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran